FREE NEET Biology Practice MCQ Test: Principles Of Inheritance And Variation Exercise 3 Questions Answers With Detailed Explanations [PDF]

Principles Of Inheritance And Variation Topic Based

Question : 1

In hybridization, Tt × tt gives rise to the progeny of ratio


Answer: (c)

Crossing of individuals having dominant phenotype with its homozygous recessive is a test cross, which can be represented as:

</p>principles-of-inheritance-and-variation-neet-mcq-1-27-114a

Question : 2

Turner's syndrome occurs due to the loss of


Answer: (c)

Question : 3

Consider the following statements regarding ABO blood group in human.

  1. It is controlled by multiple alleles.
  2. Itshows codominance.
  3. Codominance can be manifested phenotypically in human.
  4. It follows the Mendel's law of inheritance.

Which of the statments(s) given above are correct?


Answer: (a)

Statements I and II are correct. Statements III and IV are incorrect and can be corrected as

  • Codominance cannot be manifested phenotypically in humans as ABO blood group in humans is three alleles of gene I ($I^A ,I^B$ ,i).
  • ABO blood grouping system in humans does not follow Mendel's laws of inheritance.

Question : 4

In Down’s syndrome, karyotyping has shown that the disorder is associated with trisomy of chromosome number 21 usually due to


Answer: (b)

Down’s syndrome is also known as Mongolian idiocy or mongolism. In Langdon Down of England (1866) studied the Mongolian idiocy and described the trisomic condition of their chromosomes. Down’s syndrome, a very common congenital abnormality arises due to the failure of separation of $21^{st}$ pair of autosomes during meiosis. Thus, an egg is produced with 24 chromosomes instead of 23. A Down’s syndrome has 3 autosomes in $21^{st}$ pair instead of 2. Total number of chromosome in this case is 2n + 1 (21st) = 47.

Question : 5

In human skin colour inheritance, the genotype with three dominant and three recessive alleles will produce


Answer: (c)

Question : 6

The genetic defect - Adenosine deaminase (ADA) deficiency may be cured permanently by:


Answer: (a)

By introducing bone marrow cells producing ADA into cells at early embryonic stages, the genetic defect adenosine deaminase (ADA) deficiency may be cured permanently. It is due to mutation.

Question : 7

Assertion (A) Sickle-cell anaemia is an autosome linked recessive trait.
Reason (R) It is controlled by a single pair of allele.


Answer: (a)

Both Assertion and Reason are true, but Reason is not the correct explanation for Assertion.

Sickle-cell anaemia is an autosomal linked recessive disorder. The gene for this disorder is present on an autosome and an individual is said to be affected only when both the genes or a pair of allele (mutated or affected) are inherited from the carrier or affected parents.

Question : 8

In a test cross involving $F_1$ dihybrid flies, more parental-type offspring were produced than the recombinant-type offspring. This indicates


Answer: (b)

If in a dihybrid test cross more parental combinations appear as compared to the recombinants in $F_2$ generation, then it is indicative of involvement of linkage. Linkage is the tendency of two different genes on the same chromosome to remain together during the separation of homologous chromosomes at meiosis. During complete linkage no recombinants are formed whereas in incomplete linkage few recombinants are produced along with parental combinations.

Question : 9

A normal-visioned man whose father was colourblind, marries a woman whose father was also colourblind. They have their first child as a daughter. What are the chances that this child would be colourblind?


Answer: (a)

Colour blindness is an X-linked disease. So, a woman whose father is colourblind will be a carrier for the disease.

principles-of-inheritance-and-variation-class-xii-Chapter-5-neet-mcq-quiz-pdf

So, the possibility of a colourblind daughter (i.e. X Xc c) in $F_1$ -generation is 0%.

Question : 10

Monosomy and trisomy can be represented as


Answer: (d)

Question : 11

If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?


Answer: (a)

Genotype of carrier parents is

principles-of-inheritance-and-variation-class-12-Chapter-5-neet-mcq-quiz-pdf

AA → normal child (25%)

Aa → carriers child (5%)

aa → affected child (25%)

Question : 12

If two persons with 'AB' blood group marry and have sufficiently large number of children, these children could be classified as 'A' blood group: 'AB' blood group : 'B' blood group in 1 : 2 : 1 ratio. Modern technique of protein electrophoresis reveals presence of both 'A' and 'B' type proteins in 'AB' blood group individuals. This in an example of


Answer: (a)

Question : 13

Which one of the following cannot be explained on the basis of Mendel's law of dominance?


Answer: (a)

According to Mendel's law of dominance, in heterozygous individuals a character is represented by two contrasting factors called alleles or allelomorphs which occur in pairs. Out of the two contrasting alleles, only one is able to express its effect in the individual. It is called dominant factor or dominant allele. The other allele which does not show its effect in the heterozygous individual is called recessive factor or recessive allele. The option (c) in the given question cannot be explained on the basis of law of dominance. It can only be explained on the basis of Mendel's law of independent assortment, according to which in a dihybrid cross, the two alleles of each character assort independently (do not show any blending) of the alleles of other character and separate at the time of gamete formation. Both the characters are recovered as such in $F_2$ generation producing both parental and new combinations of traits.

Question : 14

Identify the type of inheritance shown in the diagram.

principles-of-inheritance-and-variation-class-12-Chapter-5-neet-mcq-5-27-67-241

Answer: (b)

The type of inheritance shown in the given diagram is dominant X linked

Question : 15

An abnormal human male phenotype involving an extra X-chromosome (XXY) is a case of


Answer: (a)

Question : 16

Which of the following cell cycle event is responsible for polyploidy phenomenon?


Answer: (a)

Question : 17

Which of the diagrams represents independent assortment?

principles-of-inheritance-and-variation-neet-mcq-8-27-107

Answer: (c)

Question : 18

Assertion:
PKU leads to mental retardation.
Reason:
Phenylpyruvic acid and their derivatives are accumulated in brain in PKU.


Answer: (b)

Question : 19

In a cross between AABB × aabb, the ratio of F2 genotypes between AABB, AaBB, Aabb and aabb would be


Answer: (a)

In a cross between AABB × aabb, the ratio of $F_2$ genotypes between AABB, AaBB, Aabb and aabb would be 1 : 2 : 2 : 1.

Question : 20

Mutagens are


Answer: (c)

Mutagens may be physical agents such as X-rays, α -rays, etc., which cause mutation and chemical agents such as mustard gas, etc., which cause changes in the DNA sequence in an organism.

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